Current Issue : October - December Volume : 2012 Issue Number : 4 Articles : 6 Articles
Hydrocortisone (HC) has formed the mainstay for the management of atopic dermatitis.Hence, HC-loaded chitosan nanoparticles\r\nwere prepared by ionic crosslinking of high, low molecular weight chitosan (HMwt, LMwt CS) and N-trimethyl chitosan (TMC)\r\nwith tripolyphosphate. HC loading into CS nanoparticles was confirmed by FT-IR. The particle size of HC-loaded HMwt, LMwt,\r\nand TMC nanoparticles was increased from 243�±12, 147�±11, and 124�±9 nmto 337�±13, 222�±14, and 195�±7 nm, respectively, by\r\nincreasing the pH of CS solution. Their respective zeta potential and entrapment efficiency (EE) were significantly decreased by\r\nincreasing the pH of CS solution. The swelling ratios of HC loaded HMwt, LMwt, and TMC NPs were increased when the pH of\r\nincubating media (PBS) was increased. The same increasing trend was observed in particle size and EE of HC loaded as the CS\r\nconcentration was increased. The HC loaded CS NPs were generally nonspherical. In-vitro permeation studies showed that HC was\r\nefficiently released from the CS NPs in QV cream while in aqueous cream CS NPs provided a sustained release for HC. Thus, it is\r\nanticipated that CS NPs are the promising delivery system for anti-inflammatory drugs....
Natural materials have been gaining lot of interest in the field of drug delivery because they are readily available, cost effective, eco-friendly, nonirritant, capable of multitude of chemical modifications, potentially degradable and compatible due to their natural origin. The present study was an attempt to evaluate the Hibiscus Esculentus gum (HEG) as a novel sustained release excipient in tablet dosage form. Matrix tablets of Aceclofenac, a model drug, were formulated by direct compression technique. For study, different proportions of HEG (10% to 30% w/w) were selected with respect to total weight of the tablet. The developed matrix tablets were evaluated for thickness, uniformity of weight, hardness, friability, drug content and in-vitro drug release study. The developed matrix tablets were found to have uniform physical appearance, thickness, weight, drug content and adequate hardness. All the formulations developed were found to follow zero order drug release kinetics. The results of in-vitro release revealed that, as the percentage of HEG in the tablet was increased, the drug release from the formulations retarded this suggest that HEG is useful sustained release excipient in the preparation of matrix tablet....
Piroxicam (NSAID) a poorly soluble drug is widely used in the painful indications like rheumatoid and osteoarthritis. The dissolution rate of piroxicam can be increased by formulating it into orodispersible tablets, as these dosage forms disintegrate very rapidly into fine suspension of drug particles resulting in higher surface area of drug. Though, several disintegrants are available, there is continuous need to develop newer disintegrants to have more disintegration and dissolution efficiency. The present research work involves preparation, characterization and evaluation of starch maleate as a super disintegrant. The prepared starch maleate was found to be free flowing and amorphous. FT-IR studies revealed the formation of ester, when starch and maleic anhydride acid were reacted with DMSO in the presence of acetone. The disintegrating nature of starch maleate (5%) was found to be very less, when compared to sodium starch glycolate. In-vitro release of piroxicam was also found to be greater i.e., 99.89% in 10 minutes in the formulations employing starch maleate as disintegrant. Therefore, starch maleate a new modified starch was found to be a promising disintegrant in the formulation of orodispersible tablets of poorly soluble drugs....
Hybrid anion exchange hollow fiber membranes (HAEHFMs) based on bromomethylated poly(2,6-dimethyl-1,4-phenylene\r\noxide) (BPPO) are proposed as potential drug carriers for four anionic model drugs, including the sodium salts of benzoate\r\n(NaBS), salicylate (NaSA), meta-amino salicylate (NaMAS), and loxoprofen (NaLS). The results of the static loading and release\r\nexperiments suggest that electrostatic interaction, hydrogen bonding, and hydrophobic interaction are the main interaction\r\npatterns between the membrane and the drugs. And they are directly influenced by the external phase conditions and the drug\r\nphysicochemical characteristics, such as structure, molecular weight, dissociation (pKa), and hydrogen bonding capability. Among\r\nthe four different drugs, NaSA and NaMAS appear to be the most suitable for controlled release by the HAEHFM due to their\r\nexcellent adsorption/release behaviors....
In recent development of novel drug delivery system it is observed that amongst the various natural polymers one of the most deserving polymers for various drug delivery systems is gellan gum. Gellan gum is repeating unit of the polymer is a tetrasaccharide, which consists of two residues of D-glucose and one of each residue of L-rhamnose and D-glucuronic acid. Gellan gum, originally a food ingredient, has been used to develop novel pharmaceutical formulation; it can be used in nasal drug delivery, ophthalmic drug delivery, in situ gel formulation, tablet excipient. Gellan gum is used primarily as a gelling agent, alternative to agar, in microbiological culture. Various significant works has been carried out in combination with other polymer to develop sustained and targeted formulation. On Gellan gum various new works are being carried out to develop new derivatives....
Bone-seeking (osteotropic) drug delivery systems (ODDS) represent an\r\ninteresting solution for targeting different types of drugs to the bones. In particular,\r\nanticancer and antibacterial agents could take advantage of such therapeutic strategy. We\r\nhave recently developed an innovative approach to this aim: a new osteotropic biomaterial\r\nwas prepared, based on the conjugation of a poly(lactide-co-glycolide) (PLGA) with the\r\nbisphosphonate drug alendronate (PLGA-ALE); its hemo- and cytocompatibility were\r\nverified. Starting with this copolymer, an osteotropic nanoparticle system (NP) was produced\r\nfor the targeted delivery of antineoplastic drugs to osteolytic bone metastases; in particular,\r\ndoxorubicin was tested as a model drug. The in vitro and in vivo results of the new ODDS\r\nare validated in this article. All the experimental data confirmed that the drug retained its\r\nactivity after loading in the PLGA-ALE NP; they can be thus considered a new promising\r\nstrategy for active targeting of drugs to bone tissues in different pathological situations....
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